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Iodoacetic acid inhibits USP2. 1 / 1

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"Interestingly, preincubation of iodoacetic acid (IAA), a cysteine alkylating agent, with USP2 completely inhibited the binding of biotin-GA to USP2 (Supporting Information Fig. S8), suggesting that GA may covalently bind to the cysteine(s) of USP2, which is consistent with previous reports that GA can covalently bind to its targets through cysteine residues56."

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Iodoacetic acid inhibits USP2. 1 / 1

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