IndraLab

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COPS5 activates ZEB1. 5 / 5
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"Overall, these results demonstrate that CSN5 contributes to RCC cell's metastasis and EMT by increasing ZEB1 expression.As dysregulation of CSN5 upregulated or downregulated ZEB1 protein but not ZEB1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, overexpression of CSN5 in ACHN cells led to a pronounced increase in ZEB1 protein stability ( Fig. 4 D)."
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"Conversely, CSN5 silencing in ACHN cells reduced ZEB1 stability ( Fig. 4 D)."
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"Zhang et al 28 found that Jab1 promotes epithelial-mesenchymal transition by inhibiting ZEB1 degradation, and Jab1 overexpression is correlated with poor OS in patients with renal cell carcinoma."
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"Thus, activated CSN5 prevents ZEB1 degradation and maintains its protein stability, resulting in EMT and tumor metastasis (Gao et al., 2022)."
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