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5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate inhibits KCNA3. 2 / 2
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"The estimated value of the half-blocking concentration (EC 50 ) was about 5.76 µM. Among non-prenylated flavonoids, acacetin and chrysin inhibited Kv1.3 channels in Jurkat T cells when applied at the concentration of 30 µM, whereas baicalein, wogonin, and luteolin were ineffective at this concentration."
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"Acacetin was also shown to attenuate mouse ALI induced by endotoxin by augmenting HO-1 activity (Wu et al., 2018) and to block kv1.3 channels and inhibit human T cell activation (Zhao et al., 2014)."
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