IndraLab

Statements

NEK2 phosphorylates NPM1. 7 / 7
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"Mechanistically, ATM activates phosphatase PP1, which antagonizes Nek2-dependent phosphorylation of nucleophosmin (NPM), thereby liberating ARF from NPM and rendering it susceptible to degradation by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26882840
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"Interestingly, a recent report demonstrated that ATM kinase negatively regulates ARF by ubiquitin dependent degradation : ATM activated protein phosphatase 1 (PP1) antagonized Nek2 dependent phosphorylation of nucleophosmin (NPM) to liberate ARF from NPM and render it susceptible to degradation by the ULF E3-ubiquitin ligase [XREF_BIBR]."
24704793
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"Furthermore, we show that numatrin is phosphorylated by wild type but not kinase-death Nek2A."
15388344
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"Mechanistically, ATM activated protein phosphatase 1, which antagonized Nek2-dependent phosphorylation of nucleophosmin (NPM), thereby liberating ARF from NPM and rendering it susceptible to degradation by the ULF E3-ubiquitin ligase."
23851489
sparser
"Upon IR-induced DNA damage, which results in the activation of ATM and PP1, the Nek2-induced phosphorylation of NPM is downregulated."
35056661
sparser
"Interestingly, a recent report demonstrated that ATM kinase negatively regulates ARF by ubiquitin-dependent degradation: ATM-activated protein phosphatase 1 (PP1) antagonized Nek2-dependent phosphorylation of nucleophosmin (NPM) to liberate ARF from NPM and render it susceptible to degradation by the ULF E3-ubiquitin ligase [ xref ]."
24704793
reach
"Mechanistically, ATM activated protein phosphatase 1, which antagonized Nek2 dependent phosphorylation of nucleophosmin (NPM), thereby liberating ARF from NPM and rendering it susceptible to degradation by the ULF E3-ubiquitin ligase."
23851489