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Mutated ATXN3 decreases the amount of ATXN2. 1 / 1

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"This work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly (A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease."

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IndraLab

Statements

Mutated ATXN3 decreases the amount of ATXN2. 1 / 1

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