IndraLab

Statements

OTUD5 binds MYC. 3 / 3
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"A previous report showed that the DUB activity of DUBA is dependent on S177 phosphorylation. [ xref ] We also found that inactive mutation of S177 decreased the expression of FLAG‐DUBA and completely failed to increase MYC‐DUBA expression (Figure  xref ; Figure xref , Supporting Information)."
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"Consistently, overexpression of FLAG‐DUBA enhanced MYC‐DUBA expression in BV2 cells (Figure  xref ; Figure xref , Supporting Information)."
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"Inactive mutation of D221 and C224 partially reduced expression levels of FLAG‐DUBA and MYC‐DUBA (Figure  xref ; Figure xref , Supporting Information), indicating that both D221 and C224 residues are required for the self‐deubiquitination of DUBA."
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