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UCHL1 activates cell migration. 15 / 18
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"UCH-L1 promotes cell migration in H157 cells."
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"In the Transwell and wound healing assays, we found that knockdown of UCHL1 significantly reduced cell migration, motility, and invasiveness."
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"This is consistent with our previous finding in H157 cells that UCH-L1 increases cell migration by modulating Akt activation [XREF_BIBR]."
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"We have further demonstrated that knockdown of UCHL1 decreased cell migration and invasion in a manner that was concomitant with less pseudopod formation in a 3D collagen matrix and significantly redu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In our previous report, we demonstrated that UCH-L1 promotes prostate cancer cell migration and invasion through EMT induction [11]."
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"UCHL1 might promote SCNEC cell migration and invasion by reducing PROX1 ubiquitination ."
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"UCH-L1 stimulates prostate cancer cell migration and invasion as well by promoting epithelial-to-mesenchymal transition (EMT) [XREF_BIBR]."
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"Moreover , in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line117 ."
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"Zhang et al (119) found that UCHL1 is highly expressed in HNSCC tissues and contributes to the proliferation and metastasis of HNSCC.Furthermore, Li et al (120) found that cell migration is markedly enhanced by UCHL1 expression."
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"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 7–119, whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line ."
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"The overexpression of UCH-L1 in the RWPE1 cells increased cell migration 3-fold."
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"Overexpression of UCH-L1 remodeled its actin cytoskeleton, increased its cell migration and impacted its important proteins."
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"We confirmed that H 2 O 2 regulates tumor invasion and that UCH-L1 significantly increases both cell migration and H 2 O 2 generation."
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"Phenotypically, UCHL1 inhibition remarkably blocked cell migration."
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"We found that UCH-L1 expression increases apoptotic resistance in the adenocarcinoma cell line (H838) and promotes cell migration in the H157 squamous cell carcinoma cell line."
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