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UCHL1 activates cell migration. 15 / 18
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"We found that UCH-L1 expression increases apoptotic resistance in the adenocarcinoma cell line (H838) and promotes cell migration in the H157 squamous cell carcinoma cell line."
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"Moreover , in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line117 ."
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"In our previous report, we demonstrated that UCH-L1 promotes prostate cancer cell migration and invasion through EMT induction [11]."
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"In the Transwell and wound healing assays, we found that knockdown of UCHL1 significantly reduced cell migration, motility, and invasiveness."
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"We have further demonstrated that knockdown of UCHL1 decreased cell migration and invasion in a manner that was concomitant with less pseudopod formation in a 3D collagen matrix and significantly redu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recently, UCH-L1 has been found to increase cancer cell migration and invasion by modulating hydrogen peroxide generated by NADPH oxidase 4 (NOX4)."
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"UCH-L1 promotes cell migration in H157 cells."
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"This is consistent with our previous finding in H157 cells that UCH-L1 increases cell migration by modulating Akt activation [XREF_BIBR]."
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"Overexpression of UCH-L1 remodeled its actin cytoskeleton, increased its cell migration and impacted its important proteins."
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"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line 117 ."
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"UCHL1 might promote SCNEC cell migration and invasion by reducing PROX1 ubiquitination ."
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"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 7–119, whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line ."
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"UCH-L1 stimulates prostate cancer cell migration and invasion as well by promoting epithelial-to-mesenchymal transition (EMT) [XREF_BIBR]."
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"Phenotypically, UCHL1 inhibition remarkably blocked cell migration."
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"We confirmed that H 2 O 2 regulates tumor invasion and that UCH-L1 significantly increases both cell migration and H 2 O 2 generation."
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