IndraLab

Statements

Mutated USP8 activates POMC. 2 / 2

| 2

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reach

"It is expected that USP8 mutations deregulate these molecules to drive ACTH production and secretion."

25675982

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reach

"While USP8 mutations were less likely to enhance tumorous ACTH hypersecretion via EGFR mediated activation, the presence of USP8 mutations may predict favorable responses to the somatostatin analog pasireotide, which exhibits high affinity for SSTR5."

26578638

INDRA sources:

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IndraLab

Statements

Mutated USP8 activates POMC. 2 / 2

INDRA sources:

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