IndraLab

Statements

Mutated USP8 activates POMC. 4 / 4
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"The upregulated mutant USP8 upon EGFR transfection enhanced POMC (Proopiomelanocortin), a polypeptide precursor produced by the anterior pituitary acting as a promoter which undergoes in cleavage and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33600786
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"USP8 mutations also increase the promoter activity of POMC by stabilizing EGFR signaling."
36672445
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"It is expected that USP8 mutations deregulate these molecules to drive ACTH production and secretion."
25675982
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"While USP8 mutations were less likely to enhance tumorous ACTH hypersecretion via EGFR mediated activation, the presence of USP8 mutations may predict favorable responses to the somatostatin analog pasireotide, which exhibits high affinity for SSTR5."
26578638