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USP12 decreases the amount of NOS2. 3 / 3
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"USP12 deficiency promoted the expression of inducible nitric oxide synthase (iNOS) in MDSCs by inhibiting the p65-NF-κB signaling pathway, and MDSCs with high iNOS expression inhibit T-cell function, resulting in poorer tumor response to chemotherapy [86]."
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"Consistent with this possibility, over-expression of USP12 robustly reduced both LPS and IFNγ-induced iNOS protein levels (data not shown) which is thematically consistent with the effects of PHLPP on[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In RAW 264.7 macrophages, the ablation of USP12 inhibited the induction of LPS-induced iNOS and IL-6 expression but failed to alter IFN-β synthesis [ 19 ]."
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