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USP37 activates vpx. 2 / 2

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"In this study, we demonstrated that deubiquitinase USP37 effectively inhibits the Vpx-mediated degradation and antiviral and anti-retrotransposition activities of SAMHD1 (Fig. 1, 2 and 8)."

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"Interestingly, USP37 could enhanced the stability of SAMHD1 in the absence of Vpx or SAMHD1 mutant resistance to Vpx-mediated degradation (Fig. 5B)."

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USP37 activates vpx. 2 / 2

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