IndraLab

Statements


Modified ATXN3 increases the amount of CHEK1. 4 / 4
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"Indeed, ectopic expression of Flag-ATX3 in A549 cells nicely upregulated the endogenous level of Chk1, and promoted the stability of Chk1 after CHX treatment."

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"In subsequent experiments, we investigated whether overexpression of ATX3 upregulates the steady-state Chk1 level."

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"If ATX3 stabilizes Chk1, then forced expression of ATX3 should upregulate the steady-state level and stability of Chk1."

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"Indeed, transient lentiviral expressions of ATX3 in WT and KO cells caused higher levels of Chk1 than control cells transfected with vector."