IndraLab

Statements

USP15 deubiquitinates BARD1. 7 / 7
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"Other epigenetic modifications associated with PARPi resistance includ de-ubiquitination of the BARD1 BRCT1 domain by the USP15 enzyme (52)."
34904812
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"Subsequently, USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1gamma interaction, resulting in BRCA1 and BARD1 retention at DSBs."
30874560
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"XREF_FIG, USP15 deubiquitinated the BRCT domain of BARD1 in vitro."
30874560
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"USP15 deubiquitinates BARD1 BRCT domain."
30874560
reach
"XREF_FIG, USP15 deubiquitinated BARD1 BRCT domain in vitro, and promoted BARD1-HP1gamma interaction."
30874560
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"Deubiquitination of BARD1 BRCT domain by USP15 assisted BRCA1 retention at DSBs and causes PARPi resistance [116]."
32563252
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"Because the C terminal of BARD1 is important for its functions in HR, we then investigated if USP15 deubiquitinates BARD1 BRCT domain in vitro and in vivo."
30874560