IndraLab

Statements

BRAF bound to HRAS is active. 3 / 3
3 |
signor
"Association of B-Raf with immobilized Ras occurred independently of prior stimulation of cells with serum, suggesting that primarily the production of GTP-Ras by mitogen stimulation is critical for the formation of B-Raf_GTP-Ras complexes."
7706312
signor
"The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases."
21779497
signor
"BRAF kinase is a downstream target of KRAS and activates the MAPK pathway."
18098337