IndraLab

Statements

(+)-artemisinin inhibits NLRP3. 10 / 10
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"Thus, artemisinin was shown to inhibit NF-κB activity and NALP3 activation in APPswe/PS1dE9 double-transgenic mice in a relative early stage of AD pathogenesis, preventing tissue damage."
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"In a transgenic mouse model with AD, artemisinin therapy has been shown to reduce the activity of NLRP3 inflammasomes."
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"Artemisinin can reduce the oxidative stress reaction due to its NLRP3-regulating ability (47) ."
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"Fenamate NSAIDs [ 130 ] and antimalarial drug artemisinin [ 131 ] could inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models."
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"For example, benzylisothiocyanate (126), stavudine (127), and artemisinin (128) all have shown therapeutic effects on AD mice by inhibiting NLRP3 activation.5.3 Regulation of phenotypic variations in microglia."
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"The pretreatment with artemisinin could significantly prevent the activation of NF-κB and NLRP3 inflammasomes in angiotensin II (Ang II)-induced injury of the human kidney 2 (HK-2) cells."
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"Artemisinin can downregulate the NF-kappaB and NLRP3 pathway to attenuate tubulointerstitial fibrosis in subtotal nephrectomized (SNx) rats, which is consistent with the results observed in Ang II treated human kidney 2 (HK-2) cells."
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"Artemisinin also sequentially inhibited assembly of NLRP3 with ASC and caspase-1 in a dose-dependent manner ( Fig. 3 B)."
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"Artemisinin treatment also reduced the neuritic plaque burden and NLRP3 inflammasome activity in an AD transgenic mouse model."
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"Artemisinin administration suppressed activation of NF-kappaB signaling and the NLRP3 inflammasome in the aorta, likely due to activation of AMP activated protein kinase (AMPK) signaling in aortic macrophages XREF_BIBR."
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