IndraLab

Statements

PDH activates mutated BAP1. 4 / 4
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"These results indicate that inhibition of PDH phosphorylation by PDHK1 inhibitions decreases BAP1 mutant UM cell growth via cell cycle arrest."
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"Moreover, we shown that inhibition of PDH phosphorylation reduces BAP1 mutant UM cell growth by induction of cell cycle arrest."
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"Suppression of PDH phosphorylation significantly decreases UM cell growth and glycolytic abilities of BAP1 mutant UM cells, but not BAP1 wild type UM cells."
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"Our results suggest that PDH inactivation causes increased glucose utilization in BAP1 mutant UM."
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