IndraLab

Statements

5-HT inhibits KCNA5. 8 / 8
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"Taken together, KMUP-1 alone increased Kv1.5 and it also reversed 5-HT-inhibited Kv1.5 protein, suggesting that KMUP-1 is not simply an inhibitor of 5-HT-mediated PKC signaling, but might have the direct actions on AC/PKA pathways."
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"Surprisingly, in addition to increases in Kv1.5 channel protein with KMUP-1, KMUP-1 also reversed 5-HT inhibition of Kv1.5 and this effect was markedly blunted in combination with the PKC activator PMA."
25999786
sparser
"5-HT-inhibited Kv1.5 protein was unaffected by the PKA inhibitor KT5720 but significantly affected by the PKC inhibitor chelerythrine, suggesting that 5-HT is not involved in cross-talk with AC/PKA cascades xref , xref but exclusively involved in the PKC pathway in rat PASMCs."
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"KMUP-1 modulation of 5-HT-inhibited Kv1.5 proteins via the PKC pathway."
25999786
sparser
"Notably, KMUP-1 reversed 5-HT-inhibited Kv1.5 protein and this effect was attenuated significantly by adding the PKC activator PMA, suggesting that KMUP-1 did modulate the 5-HT-mediated PKC pathway (Fig xref )."
25999786
sparser
"Additionally, 5-HT inhibition of Kv1.5, Kv2.1 and BK Ca channel proteins in PASMCs was reversed by KMUP-1 in a dose-dependent manner."
25999786
sparser
"Notably, KMUP-1 reversed 5-HT-inhibited Kv1.5 protein and this response was significantly attenuated by co-incubation with the PKC activator PMA, suggesting that 5-HT-mediated PKC signaling can be modulated by KMUP-1."
25999786
sparser
"5-HT inhibition of Kv1.5 protein was reversed by KMUP-1 (1 μM), chelerythrine (1 μM), KMUP-1+PMA (1 μM) or KMUP-1+chelerythrine, but not affected by the PKC activator PMA (1 μM)."
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