IndraLab

Statements

Cdk-4 activates USP17L2. 11 / 11
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"CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1."
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"CDK4/6 phosphorylates and activates DUB3."
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"CDK4/6 dependent activation of DUB3 regulates cancer metastasis through SNAIL1."
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"For instance, Snail1-dependent p53 repression regulates the expansion and activity of tumour-initiating cells in breast cancer [33], CDK4/6-dependent activation of DUB3 regulates cancer metastasis through Snail1 [27]."
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"CDK4/6 mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a transcription factor that promotes epithelial-mesenchymal transition (EMT) and, therefore, invasiveness."
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"In BETi-resistant prostate cancer cells, CDK4/6-mediated serine phosphorylation regulates DUB3 activity [ 17 ], and we hypothesized that CDK4/6 is involved in UCHL5 overexpression in OTX015-R cells."
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"These results showed that CDK4/6 inhibition suppresses CRCs mainly through destabilizing YAP1 and subsequently impairing expressions of target genes.2.2 Identification of the DUB3 as the bona fide deubiquitinase of YAP1."
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"As a linker between CDK4/6 and SNAIL1, DUB3 activation by CDK4/6 is essential to deubiquitinate SNAIL1."
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"27 The main mechanism might be that CDK4/6‐mediated activation of DUB3 is essential to deubiquitinate and stabilize Snail."
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"The underlying mechanism might be attributed to the inhibition of the CDK4/6-mediated activation of the DUB3 deubiquitinase."
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"Besides, CDK4/6 mediated activation of DUB3 has been reported to be essential to deubiquitinate and stabilize SNAIL1, a key factor promoting EMT and involved in breast cancer metastasis 34."
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