IndraLab

Statements

UCHL1 activates BACE1. 5 / 5
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"Interestingly, the results indicated that the overexpression of UCHL1 decreased BACE1, and also alleviated the METH-induced up-regulation of BACE1 obviously ( Fig. 4 B, B1)."
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"These studies demonstrate that decreased UCHL1 activity or UCHL1 gene deficiency promote BACE1 degradation and increase amyloid β production."
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"The circular RNA circular RNA sponge for miR-7 (ciRS-7) inhibits the expression of UCHL1 to promote APP and BACE1 degradation by inhibiting the translation of NF-κB and inducing its cytoplasmic localization (Shi et al., 2017)."
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"Besides, UCHL1 could promote BACE1 (beta-amyloid cleavage enzyme 1) degradation and decrease Abeta production in vivo and in vitro (Zhang et al., 2012)."
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"As indicated in Fig. 4 A and A1, UCHL1 siRNA treatment resulted in the up-regulation of BACE1 and aggravated the METH-induced up-regulation of BACE1 in primary neurons."
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