IndraLab

Statements

TP53 bound to HSP90 activates TP53. 3 / 3
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"Recent studies have reported that HSP90 can bind to mutp53 and reduce mutp53 degradation mediated by MDM2."
26271008
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"It was observed that CeO NPs treatment led a reduction in the level of interaction between mutp53 and Hsp90 or Hsp70 (Fig. 4f g), suggesting that CeO NPs induced the dissociation of mutp53 from Hsp90 or Hsp70, thereby affecting the stability of mutp53 protein."
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"We further validated our hypothesis by introducing Hsp90 inhibitors, which could disrupt the interaction between p53 and Hsp90 and partly restore the suppressive function of p53."
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