IndraLab

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THBS1 binds VLDLR. 11 / 12
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"Using adenovirus-mediated gene transfer experiments, we demonstrate that the very low density lipoprotein receptor can also bind and internalize TSP-1."
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"has confirmed the interaction between the VLDLR and TSP-1."
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"The very low-density lipoprotein receptor inside the membrane of capillary endothelial cells binds TSP-1 and mediates the inhibition of cell cycle progression via the Akt and MAPK pathway [XREF_BIBR]; therefore, targeting the TSP-1/CD47/NO signalling axis may promote the healing of skin grafts [XREF_BIBR]."
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"TSP-1, by binding the CD36 receptor or the VLDL receptor, inhibits intracellular signaling and cell cycle progression, inducing EC apoptosis [211] ."
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"Our results identified a novel role of Vldlr in consolidating extracellular signals to regulate cardiomyocyte cell cycle activity and survival, and the overall suppressive TSP-1-Vldlr signal may contribute to the poor cardiac repair capacity of adult mammals."
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"And the proliferation of microvascular endothelial cells can be inhibited by the interaction of TSP-1 with very low density lipoprotein receptor (VLDLR) ( xref )."
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"The proliferation of HMVECs could be inhibited by the interaction of TSP1 with the very low density lipoprotein receptor (VLDLR)."
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"Recently, it was also shown that thrombospondin-1 binds to Apoer2 and VLDLR in the brain where it participates in the chain migration of postnatal neurons along the rostral stream."
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"Similarly, we identified Thrombospondin-1 (THBS1), which binds to LRP8 (a.k.a. APOER2) and VLDLR receptors, also receptors for reelin, and seems to play a role in murine postnatal neuronal migration, as well as in synaptogenesis XREF_BIBR, XREF_BIBR."
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"Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration."
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"In contrast to these antiangiogenic phenomena, TSP-1 may also bind ApoER2 (apolipoprotein E receptor 2) and VLDLR to promote neuronal migration."
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