IndraLab

Statements

USP2 leads to the deubiquitination of NBN. 2 / 2
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"Taken together, these results suggest that USP2 prevents premature disassembly of the MRN complex in RECQL4-defective cells by counteracting the ubiquitination of NBS1."
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"As SKP2 E3 ligase is responsible for NBS1 ubiquitination during the DSB response, USP2 may also be able to reduce NBS1 ubiquitination through interaction with SKP2, although the importance of this mode of action in stabilizing the MRN complex during the DSB response has not yet been determined.The MRN complex is one of the key factors in the DSB response, and its recruitment to DSB sites and its roles in the DSB response have been well documented in many previous studies."
36436562