IndraLab

Statements

Metformin inhibits USP7. 2 / 2
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"USP7 promotes the growth of non-small cell lung cancer cells by stabilizing Ki-67 protein, while metformin can inhibit the proliferation of esophageal cancer by upregulating USP7, suggesting that USP7 plays different roles in different types of tumors [50-52], USP4 and USP15 can stabilize TGF-β receptors and increase TGF-β-mediated EMT, leading to metastasis of hepatocellular carcinoma and glioblastoma [53-55]."
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"Metformin is primarily used to regulate AMPK-mTOR signaling, inhibits HAUSP activity and enhances growth inhibition in cancer cells."
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