IndraLab

"Like A20 and OTUD1, otubain 2 (OTUB2) is a DUB of the ovarian tumour protease subfamily. xref Recent studies have found that OTUB2 regulates tumourigenesis and/or progression of multiple cancers. xref , xref , xref For example, OTUB2 deubiquitinates and stabilises U2AF2 and thereby promotes tumourigenesis of non‐small cell lung cancer. xref Besides, OTUB2 promotes breast cancer metastasis by deubiquitinating and activating YAP/TAZ. xref OTUB2 has also been shown to inhibit antitumour immunity by disrupting the ubiquitination and degradation of PD‐L1 on tumour cells. xref In sharp contrast, OTUB2 inhibits tumourigenesis and progression of tongue and oesophageal squamous cell carcinoma by mediating the deubiquitination and activation of STAT1. xref Upon virus infection, OTUB2 inhibits type I IFN production by deubiquitinating TRAF3 and TRAF6, resulting in impaired cellular antiviral response. xref Moreover, OTUB2 has also been shown to fine‐tune DNA repair by suppressing RNF8‐mediated ubiquitination in response to DNA double‐strand breaks. xref However, the pathophysiological function of OTUB2 in intestinal inflammation remains unknown."

"These findings suggest that OTUB1 and OTUB2 negatively regulate virus triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6."