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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN8A inhibits TNFSF11. 2 / 2

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"In this study, we showed that MED could inhibit receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation and the expression of three well-known osteoclast markers such as tartrate resistant acid phosphatase, calcitonin receptor, and cathepsin K in bone marrow derived macrophages."

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"Taken together, we demonstrate for the first time that MED can suppress RANKL induced osteoclast differentiation in vitro and ovariectomy induced osteoporosis in vivo, suggesting that MED is a potential lead compound for the development of novel drugs for osteoporosis treatment."

22678021

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...