IndraLab

Statements

HIF hydroxylates OTUB1. 5 / 5
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"Overall, these data led us to hypothesize that OTUB1 hydroxylation by FIH may be a link in the association of FIH with an alteration in cellular metabolism."
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"For example, hydroxylation of OTUB1 by factor inhibiting HIF (FIH) leads to a profound change in the interaction of OTUB1 with proteins important in cellular metabolism."
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"Therefore, a possible contributory mechanism for the anti-inflammatory activity of hydroxylase inhibitors is through altered FIH-dependent hydroxylation of OTUB1, leading to differential metabolism at inflamed sites."
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"In our study, we found that N22, the site of OTUB1 hydroxylation by FIH, is located in a region of the protein that may be key to determining its activity."
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"These data provide a mechanistic link between FIH-dependent hydroxylation of OTUB1 and alterations in cellular metabolism and contribute a further level of understanding to the vital link between cellular oxygen-sensing mechanisms and the control of cellular metabolism."
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