IndraLab

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IL1A activates IL1R1. 82 / 86
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"The TLRs recognise conserved molecules derived from bacteria, fungi and viruses and contribute towards the innate immune response whilst the IL-1Rs are activated by the pro-inflammatory cytokines, IL-1α, IL-1β, IL-18 and IL-33 [ xref ]."
20525168
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"Taken together, these data suggest that the inflammatory airway response to intranasal challenge with Ova initiated by CFA and Ova immunization requires signaling through the IL-1R1 by IL-1alpha but not by IL-1beta."
26978520
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"The other speculation is that IL-33 induces IL-1alpha and IL-1beta (data not shown), and then IL-1alpha and IL-1beta in turn activate IL-1R to induce iNOS in macrophages XREF_BIBR."
24586149
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"The other speculation is that IL-33 induces IL-1α and IL-1β (data not shown), and then IL-1α and IL-1β in turn activate IL-1R to induce iNOS in macrophages xref ."
24586149
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"While the majority of the work on IL-1 signaling in NPCs has focused on IL-1β, IL-1α also activates the IL-1R1 and direct effects on NPCs have been observed."
20833246
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"In addition to promoting tumour progression, by controlling Treg recruitment via CCL22 signalling, however, IL-1A mediated IL-1R1 signalling has also been reported to have anti-tumour functions."
29760166
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"In this context, in response to damage or noxious stimulus assault, the initial pro inflammatory IL-1R1 signaling can be mediated by IL-1alpha, while chronic inflammatory response even without any pathogen presence may then be sustained by both IL-1alpha and IL-1beta."
23438818
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"Because IL-1α was not detected on the surface of EVs, it is not clear how IL-1α activates IL-1R1."
34010648
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"In the context of senescence, this regulation was a consequence of IL-1R signaling specifically activated by IL-1alpha but not IL-1beta."
20148189
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"Altogether, inflammatory cytokine IL-1α activates IL1R, where the signal is transduced by p38-MAPK, resulting in the activation of Piezo1 expression through TFs, ATF2/CREBP1 and HNF4."
35602590
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"Following EGFR activation IL-1α is released and activates IL-1R on keratinocytes creating a second autocrine loop leading to the activation of NF-κB signaling that modifies expression of specific keratinocyte genes involved in tumor formation including increasing expression and release of CXC ligands such as CXCL1 ( xref )."
27330189
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"IL-1R is activated by its ligands IL-1α and IL-1β [ xref ; xref ]."
22137885
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"In addition, IL-1α, which also activates IL-1R, could contribute to the inflammatory response in vivo ."
23702978
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"IL-1α is primed and ready in skin resident immune cells for rapid action and, unlike IL-1β which is only biologically active in its cleaved mature form xref – xref , IL-1α activates IL-1R1 in both its cleaved mature and precursor pro forms xref ."
38643253
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"IL-1α on the plasma membrane activates IL-1R [ xref ] and triggers a signaling cascade that degrades IRAK1 and IkBα to allow nuclear transition of NF-κB [ xref , xref ]."
36980256
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"IL-1R is activated by its ligands IL-1alpha and IL-1beta [XREF_BIBR; XREF_BIBR]."
22137885
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"IL-1R is activated by both IL-1α and IL-1β, which have unique and shared functions ( xref )."
38363547
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"These include CXCL1/KC and probably CXCL2, 5, and 8, which recruit neutrophils from limbal capillaries to the corneal stroma, and IL-1alpha and IL-1beta, which then feedback to activate the IL-1R1 and MyD88 pathway in macrophages and most likely also in resident corneal epithelial cells and stromal fibroblasts."
20826748
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"The family contains IL-1alpha and IL-1beta, which both activate the same receptor, IL-1R, [XREF_BIBR] and IL-18 which activates the IL-18R [XREF_BIBR], [XREF_BIBR]."
25085021
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"The capacity of membrane bound IL-1alpha to activate IL-1R1 signaling in an intracrine and paracrine manner on surrounding cells has important implications for the induction and maintenance of local inflammatory responses."
27434011
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"IL-1α and high mobility group box 1 (HMGB1), which activate IL-1R1 and TLR4, respectively, were proposed to play a central role in the phenotype observed and the expression levels of both molecules were increased in IL-1R8-deficient mice."
27148268
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"Since IL-1Ra does not activate IL-1 receptor cell signaling cascades and IL-1Ra production can be induced by IL-1beta and/or IL-1alpha, it is plausible that the increased IL-1Ra in the ascites and the associated poor prognosis is due to secreted IL-1beta signaling [XREF_BIBR]."
21765834
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"By contrast, IL-1R is activated by IL-1α and IL-1β, which are produced by host cells xref ."
21720387
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"We also show that P. aeruginosa activates NF-κB in macrophages through both the TIR-containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF-dependent pathways, and that IL-1α and IL-1β activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
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"Addition of recombinant IL1A (rIL1A) rescued both IL1R1 signalling and IL6 secretion in the rapamycin treated cells (XREF_FIG)."
26147250
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"We thus propose that the presence of IL-1alpha or IL-1beta is sufficient to trigger IL-1R pathway, an essential component in the development of innate response to acute M. tuberculosis infection, but may not be sufficient for full control of the infection."
25400917
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"Although both IL-1alpha and IL-1beta can activate IL-1R and MyD88 signaling, their cellular source and post-translational processing are different [XREF_BIBR]."
22057887
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"Taken together, these data show that either IL-1α or IL-1β can activate IL-1R1 in P. aeruginosa keratitis and that IL-1R1 has an essential role in regulating the inflammatory response to P. aeruginosa in the cornea."
20826748
eidos
"Although both IL-1alpha and IL-1beta activate IL-1R1 , we initially focused on the role of IL-1beta ."
37060806
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"The secreted IL-1alpha may further stimulate the cells through MyD88 independent IL-1R pathway that initiates a late phase response [XREF_BIBR, XREF_BIBR]."
18578886
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"IL-1 α is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts, inducing early myocardial remodeling in AMI [ xref ]."
33488934
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"Along these lines, work done by the Rock laboratory has recently shown that activation of the IL-1R1 by IL-1α is a key pathway required for neutrophil recruitment to injured cells in peripheral tissue[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19932745
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"IL-1A then (like IL-1b) activate the IL-1R1 signaling which, in turn, may trigger the downstream nuclear factor-kappa B (NFκB) and mitogen-activated protein (MAP) kinase pathways, both involved in innate and adaptative immune responses [84,85]."
35625844
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"IL-1α and IL-1β are two major cytokines able to activate IL-1R, and both of them may be released by stressed cells."
24172847
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"Because of the intermediate role of IRAK-1 in the activation of NF-kappaB after IL-1R stimulation by IL-1alpha,, we examined the correlation between the immunohistochemical expression of IRAK-1 with that of IL-1 alpha (an IL- 1R ligand) and NF-kappaB using the 306 NSCLCs placed in TMAs."
20028769
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"Two distinct cytokines, IL-1alpha and IL-1beta, can stimulate the IL-1R."
23686480
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"Because of the intermediate role of IRAK-1 in the activation of NF-kappaB after IL-1R stimulation by IL-1alpha, we examined the influence of the combined expression of these biomarkers on disease outcomes of patients with NSCLC."
20028769
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"74 Interestingly, IL-1R autocrine stimulation by IL-1alpha and downstream MyD88 activation were shown to be crucial for the establishment of the inflammation involved in RAS dependent carcinogenesis."
27569562
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"IL-1alpha or TNF-alpha alone significantly stimulated the production of IL-1Ra."
15036245
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"IL-1alpha or TNF-alpha alone, and particularly the combination of both cytokines, stimulated the production of IL-1Ra in contrast to HDF."
15036245
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"Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha, IL-1 beta, and TNF-alpha as well as the suppressive cytokine IL-1ra, we proposed that IL-1 alpha, IL-1 beta, and TNF-alpha may induce IL-1ra from mononuclear phagocytes."
8179914
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"In addition, levels of IL-1alpha were elevated after as early as 4 h of stimulation, whereas production of IL-1Ra continued to increase up to 72 h, suggesting that the early synthesis of IL-1alpha by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15036245
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"However, IL-1 alpha and IL-1 beta were better inducers of IL-1ra than was TNF-alpha."
8179914
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"IL-1 alpha or IL-1 beta at a dose of 10 ng/ml induced 3 to 6 ng/ml of IL-1ra, while TNF-alpha at a dose of 100 ng/ml stimulated only 1.4 ng/ml of IL-1ra."
8179914
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"Nonetheless, as both IL-1α and IL-1β activate IL-1Rs, these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs."
34010713
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"Membrane IL-1α activates the IL-1R1 on adjacent cells by a mechanism termed “juxtacrine”."
30995499
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"IL-1R1 receptor activation by IL-1α and/or IL-1β induces an array of factors including IL-1, IL-6 (CXCL6), IL-8 (CXCL8), interferon (IFN) α, β, and γ, defensins, matrix metalloproteinases (MMPs), C-reactive protein, etc ( xref , xref , xref )."
31788049
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"In contrast to mononuclear phagocytes, IL-1 alpha, IL-1 beta, and TNF-alpha did not induce further IL-1ra production in alveolar macrophages."
8179914
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"Membrane-associated IL-1α can activate IL-1R1 on target cells, such as T-cells or endothelial cells, in a juxtacrine manner."
24183701
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"Addition of IL-1 alpha could stimulate IL-1R, IL-1 alpha, and IL-6 mRNA synthesis in the epithelial, stromal, and endothelial components of the cornea."
8640449
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"The released IL-1alpha can now trigger the IL-1R1 on neighboring cells."
30723583
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"In contrast to IL-1beta, which must undergo proteolytically processing from its precursor pro-IL-1beta to be active, both pro-IL-1alpha and IL-1alpha can activate IL-1R and MyD88-signaling 51."
30240702
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"In agreement with the effect on Sertoli cell proliferation, IL-1ra could also abolish the morphological change seen in cells treated with IL-1alpha (not shown)."
11850120
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"IL-1 beta induced production of both IL-1Ra and IL-1 alpha at each time point and concentration tested."
7485466
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"In addition, MyD88 is involved in IL-1R signaling activated by several IL-1 family members, such as IL-1alpha, IL1beta, IL-33, and IL-36, contributing to the inflammatory response in COPD."
29658361
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"Indeed, IL1R1 can be activated by both IL-1B and IL-1A."
34290237
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"A major branch of the innate immune system is regulated by the Toll like receptors (TLRs), which are receptors for endogenous damage associated molecules released from injured cells as well as pathogen derived molecules, and interleukin-1 receptors (IL-1R), which are activated by IL-1alpha, IL-1beta and IL-18 cytokines."
25725353
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"Although both IL-1α and IL-1β activate IL-1R1, we initially focused on the role of IL-1β."
37060806
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"Mechanistically, we showed that IL-1R1 activation by IL-1A stimulus is responsible for MAPK engagement and AKT activation."
30261609
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"While IL-1R1 can be stimulated by either of two cytokines, IL-1alpha or IL-1beta, it has been shown that IL-1beta plays a pivotal role in disease pathogenesis because it not only directly stimulates IL-1R1-dependent inflammatory signaling, but is also needed for the secretion of IL-1alpha from cells."
26195813
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"In the anti-inflammatory NFKBr-IL1Ra tissue constructs, osmotic loading in the presence of inflammatory IL-1alpha increased IL-1Ra production by 93% over iso-osmotic control tissues also cultured with IL-1alpha (XREF_FIG)."
| PMC
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"IL-1alpha was used to stimulate IL-1R signaling whereas a receptor antagonist, IL-1Ra, was used to inhibit a positive feedback loop."
22931929
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"IL-1alpha was increased 2.1-fold at 6 h by 200 cGy of gamma radiation (data not shown), however, IL-1beta, IL-1RA, TNF-alpha, IL-6, and IFN-gamma were not."
21958477
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"Of note, while it can not be excluded that the association of plasma apoB with hyperinsulinemia and IR may also be related to increased production of IL-1alpha, which promotes IL-1Ra secretion, IL-1alpha is rarely found in circulation and its role in T2D in humans is less clear."
26417659
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"Interference with IL-1alpha signaling or ablation of IL-1R1 inhibited hepatocellular carcinoma (HCC) development [XREF_BIBR]."
28152513
eidos
"IL-1alpha is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts , inducing early myocardial remodeling in AMI [ 111 ] ."
33488934
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"At the cell membrane, IL-1α can bind to and activate IL-1R1 on adjacent cells, or can be released in membrane-bound apoptotic bodies, leading to further local and systemic inflammation xref ."
35729334
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"Our group has previously demonstrated overexpression of IL-1ra, which antagonizes the functions of IL-1alpha, beta, in DEN induced hepatic tumors 24, and an increase in IL-1ra over IL-1alpha, beta contributes to tumor growth 35, 36."
27253992
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"In addition, IL-1alpha, which also activates IL-1R, could contribute to the inflammatory response in vivo."
23702978
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"Neutrophil recruitment to the peritoneum in this model critically depends on IL-1R activation by IL-1α, not IL-1β, and on downstream induction of the chemokine CXCL5, and not CXCL1 or CXCL2 ( xref )."
35801586
eidos
"Because IL-1alpha was not detected on the surface of EVs , it is not clear how IL-1alpha activates IL-1R1 ."
34010648
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"One can argue that since IL-1alpha or IL-1beta stimulates IL-1Ra production, a lower level of IL-1Ra reflects less functional IL-1 due to inhibition of IL-1 signaling."
20422276
eidos
"Nonetheless , as both IL-1alpha and IL-1beta activate IL-1Rs , these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs ."
34010713
sparser
"Indeed, liver lysates containing IL-1α promote neutrophilic migration in matrigel. xref Moreover, in peritonitis, IL-1α is released from necrotic cells and subsequently activates IL-1R1 present at the surface of mesothelial cells."
27569562
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"IL-1alpha and IL-1beta are also produced, which activate an IL-1R1 and MyD88-positive feedback loop in macrophages and IL-1R on other resident cells in the cornea."
20826748
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"IL-1α is primed and ready in skin resident immune cells for rapid action and, unlike IL-1β which is only biologically active in its cleaved mature form[ xref – xref ], IL-1α activates IL-1R1 in both its cleaved mature and precursor pro forms[ xref ]."
38585803
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"We also show that P. aeruginosa activates NF-kappaB in macrophages through both the TIR containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF dependent pathways, and that IL-1alpha and IL-1beta activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
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"IL-1alpha is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts, inducing early myocardial remodeling in AMI [XREF_BIBR]."
33488934
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"The first and best-studied cytokines in this family are IL-1alpha and IL-1beta, which induce similar pro-inflammatory reactions by interacting with the interleukin-1 type 1 receptor (IL-1R1) [38]."
37569413
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"IL-1R can be activated by IL-1α and IL-1β within the inflamed comedones of acne patients [ xref ]."
38731983
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"By contrast, IL-1R is activated by IL-1alpha and IL-1beta, which are produced by host cells 15."
21720387
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"Membrane IL-1alpha activates the IL-1R1 on adjacent cells by a mechanism termed " juxtacrine "."
30995499