IndraLab

Statements

IL1A activates IL1R1. 70 / 71
2 1 | 3 48 16
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"In contrast to IL-1beta, which must undergo proteolytically processing from its precursor pro-IL-1beta to be active, both pro-IL-1alpha and IL-1alpha can activate IL-1R and MyD88-signaling 51."
30240702
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"By contrast, IL-1R is activated by IL-1alpha and IL-1beta, which are produced by host cells 15."
21720387
sparser
"Indeed, liver lysates containing IL-1α promote neutrophilic migration in matrigel. xref Moreover, in peritonitis, IL-1α is released from necrotic cells and subsequently activates IL-1R1 present at the surface of mesothelial cells."
27569562
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"IL-1alpha or TNF-alpha alone significantly stimulated the production of IL-1Ra."
15036245
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"Membrane IL-1alpha activates the IL-1R1 on adjacent cells by a mechanism termed " juxtacrine "."
30995499
sparser
"Taken together, these data show that either IL-1α or IL-1β can activate IL-1R1 in P. aeruginosa keratitis and that IL-1R1 has an essential role in regulating the inflammatory response to P. aeruginosa in the cornea."
20826748
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"IL-1alpha is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts, inducing early myocardial remodeling in AMI [XREF_BIBR]."
33488934
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"One can argue that since IL-1alpha or IL-1beta stimulates IL-1Ra production, a lower level of IL-1Ra reflects less functional IL-1 due to inhibition of IL-1 signaling."
20422276
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"Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha, IL-1 beta, and TNF-alpha as well as the suppressive cytokine IL-1ra, we proposed that IL-1 alpha, IL-1 beta, and TNF-alpha may induce IL-1ra from mononuclear phagocytes."
8179914
sparser
"The TLRs recognise conserved molecules derived from bacteria, fungi and viruses and contribute towards the innate immune response whilst the IL-1Rs are activated by the pro-inflammatory cytokines, IL-1α, IL-1β, IL-18 and IL-33 [ xref ]."
20525168
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"In addition, levels of IL-1alpha were elevated after as early as 4 h of stimulation, whereas production of IL-1Ra continued to increase up to 72 h, suggesting that the early synthesis of IL-1alpha by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15036245
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"Taken together, these data suggest that the inflammatory airway response to intranasal challenge with Ova initiated by CFA and Ova immunization requires signaling through the IL-1R1 by IL-1alpha but not by IL-1beta."
26978520
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"While IL-1R1 can be stimulated by either of two cytokines, IL-1alpha or IL-1beta, it has been shown that IL-1beta plays a pivotal role in disease pathogenesis because it not only directly stimulates IL-1R1-dependent inflammatory signaling, but is also needed for the secretion of IL-1alpha from cells."
26195813
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"A major branch of the innate immune system is regulated by the Toll like receptors (TLRs), which are receptors for endogenous damage associated molecules released from injured cells as well as pathogen derived molecules, and interleukin-1 receptors (IL-1R), which are activated by IL-1alpha, IL-1beta and IL-18 cytokines."
25725353
sparser
"IL-1R is activated by its ligands IL-1α and IL-1β [ xref ; xref ]."
22137885
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"IL-1 alpha or IL-1 beta at a dose of 10 ng/ml induced 3 to 6 ng/ml of IL-1ra, while TNF-alpha at a dose of 100 ng/ml stimulated only 1.4 ng/ml of IL-1ra."
8179914
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"IL-1 beta induced production of both IL-1Ra and IL-1 alpha at each time point and concentration tested."
7485466
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"Addition of recombinant IL1A (rIL1A) rescued both IL1R1 signalling and IL6 secretion in the rapamycin treated cells (XREF_FIG)."
26147250
sparser
"Membrane IL-1α activates the IL-1R1 on adjacent cells by a mechanism termed “juxtacrine”."
30995499
reach
"Since IL-1Ra does not activate IL-1 receptor cell signaling cascades and IL-1Ra production can be induced by IL-1beta and/or IL-1alpha, it is plausible that the increased IL-1Ra in the ascites and the associated poor prognosis is due to secreted IL-1beta signaling [XREF_BIBR]."
21765834
sparser
"The other speculation is that IL-33 induces IL-1α and IL-1β (data not shown), and then IL-1α and IL-1β in turn activate IL-1R to induce iNOS in macrophages xref ."
24586149
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"Of note, while it can not be excluded that the association of plasma apoB with hyperinsulinemia and IR may also be related to increased production of IL-1alpha, which promotes IL-1Ra secretion, IL-1alpha is rarely found in circulation and its role in T2D in humans is less clear."
26417659
eidos
"Because IL-1alpha was not detected on the surface of EVs , it is not clear how IL-1alpha activates IL-1R1 ."
34010648
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"Two distinct cytokines, IL-1alpha and IL-1beta, can stimulate the IL-1R."
23686480
signor
"Interleukin-1 receptor (il-1r) is a cytokine receptor which binds interleukin 1."
7964161
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"Because of the intermediate role of IRAK-1 in the activation of NF-kappaB after IL-1R stimulation by IL-1alpha,, we examined the correlation between the immunohistochemical expression of IRAK-1 with that of IL-1 alpha (an IL- 1R ligand) and NF-kappaB using the 306 NSCLCs placed in TMAs."
20028769
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"These include CXCL1/KC and probably CXCL2, 5, and 8, which recruit neutrophils from limbal capillaries to the corneal stroma, and IL-1alpha and IL-1beta, which then feedback to activate the IL-1R1 and MyD88 pathway in macrophages and most likely also in resident corneal epithelial cells and stromal fibroblasts."
20826748
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"Although both IL-1alpha and IL-1beta can activate IL-1R and MyD88 signaling, their cellular source and post-translational processing are different [XREF_BIBR]."
22057887
sparser
"In addition, IL-1α, which also activates IL-1R, could contribute to the inflammatory response in vivo ."
23702978
sparser
"Because IL-1α was not detected on the surface of EVs, it is not clear how IL-1α activates IL-1R1."
34010648
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"Interference with IL-1alpha signaling or ablation of IL-1R1 inhibited hepatocellular carcinoma (HCC) development [XREF_BIBR]."
28152513
sparser
"IL-1α and high mobility group box 1 (HMGB1), which activate IL-1R1 and TLR4, respectively, were proposed to play a central role in the phenotype observed and the expression levels of both molecules were increased in IL-1R8-deficient mice."
27148268
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"IL-1alpha was increased 2.1-fold at 6 h by 200 cGy of gamma radiation (data not shown), however, IL-1beta, IL-1RA, TNF-alpha, IL-6, and IFN-gamma were not."
21958477
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"74 Interestingly, IL-1R autocrine stimulation by IL-1alpha and downstream MyD88 activation were shown to be crucial for the establishment of the inflammation involved in RAS dependent carcinogenesis."
27569562
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"IL-1alpha was used to stimulate IL-1R signaling whereas a receptor antagonist, IL-1Ra, was used to inhibit a positive feedback loop."
22931929
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"We thus propose that the presence of IL-1alpha or IL-1beta is sufficient to trigger IL-1R pathway, an essential component in the development of innate response to acute M. tuberculosis infection, but may not be sufficient for full control of the infection."
25400917
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"Liposaccharides (LPS), as well as IL-1alpha and IL-1beta were found to stimulate IL-1alpha and IL-1ra, but not IL-1beta production, in Sertoli cells from immature mice."
11988319
eidos
"Nonetheless , as both IL-1alpha and IL-1beta activate IL-1Rs , these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs ."
34010713
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"The capacity of membrane bound IL-1alpha to activate IL-1R1 signaling in an intracrine and paracrine manner on surrounding cells has important implications for the induction and maintenance of local inflammatory responses."
27434011
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"In contrast to mononuclear phagocytes, IL-1 alpha, IL-1 beta, and TNF-alpha did not induce further IL-1ra production in alveolar macrophages."
8179914
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"Because of the intermediate role of IRAK-1 in the activation of NF-kappaB after IL-1R stimulation by IL-1alpha, we examined the influence of the combined expression of these biomarkers on disease outcomes of patients with NSCLC."
20028769
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"In addition, IL-1alpha, which also activates IL-1R, could contribute to the inflammatory response in vivo."
23702978
reach
"In addition to promoting tumour progression, by controlling Treg recruitment via CCL22 signalling, however, IL-1A mediated IL-1R1 signalling has also been reported to have anti-tumour functions."
29760166
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"In the anti-inflammatory NFKBr-IL1Ra tissue constructs, osmotic loading in the presence of inflammatory IL-1alpha increased IL-1Ra production by 93% over iso-osmotic control tissues also cultured with IL-1alpha (XREF_FIG)."
| PMC
signor
"Il-1ri is responsible for il-1 signaling"
9565970
reach
"In this context, in response to damage or noxious stimulus assault, the initial pro inflammatory IL-1R1 signaling can be mediated by IL-1alpha, while chronic inflammatory response even without any pathogen presence may then be sustained by both IL-1alpha and IL-1beta."
23438818
reach
"We also show that P. aeruginosa activates NF-kappaB in macrophages through both the TIR containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF dependent pathways, and that IL-1alpha and IL-1beta activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
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"Mechanistically, we showed that IL-1R1 activation by IL-1A stimulus is responsible for MAPK engagement and AKT activation."
30261609
reach
"Addition of IL-1 alpha could stimulate IL-1R, IL-1 alpha, and IL-6 mRNA synthesis in the epithelial, stromal, and endothelial components of the cornea."
8640449
eidos
"IL-1alpha is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts , inducing early myocardial remodeling in AMI [ 111 ] ."
33488934
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"Our group has previously demonstrated overexpression of IL-1ra, which antagonizes the functions of IL-1alpha, beta, in DEN induced hepatic tumors 24, and an increase in IL-1ra over IL-1alpha, beta contributes to tumor growth 35, 36."
27253992
sparser
"By contrast, IL-1R is activated by IL-1α and IL-1β, which are produced by host cells xref ."
21720387
reach
"The family contains IL-1alpha and IL-1beta, which both activate the same receptor, IL-1R, [XREF_BIBR] and IL-18 which activates the IL-18R [XREF_BIBR], [XREF_BIBR]."
25085021
reach
"The secreted IL-1alpha may further stimulate the cells through MyD88 independent IL-1R pathway that initiates a late phase response [XREF_BIBR, XREF_BIBR]."
18578886
reach
"The other speculation is that IL-33 induces IL-1alpha and IL-1beta (data not shown), and then IL-1alpha and IL-1beta in turn activate IL-1R to induce iNOS in macrophages XREF_BIBR."
24586149
sparser
"IL-1α and IL-1β are two major cytokines able to activate IL-1R, and both of them may be released by stressed cells."
24172847
sparser
"While the majority of the work on IL-1 signaling in NPCs has focused on IL-1β, IL-1α also activates the IL-1R1 and direct effects on NPCs have been observed."
20833246
reach
"The released IL-1alpha can now trigger the IL-1R1 on neighboring cells."
30723583
reach
"In the context of senescence, this regulation was a consequence of IL-1R signaling specifically activated by IL-1alpha but not IL-1beta."
20148189
reach
"Indeed, IL1R1 can be activated by both IL-1B and IL-1A."
34290237
reach
"In agreement with the effect on Sertoli cell proliferation, IL-1ra could also abolish the morphological change seen in cells treated with IL-1alpha (not shown)."
11850120
sparser
"Nonetheless, as both IL-1α and IL-1β activate IL-1Rs, these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs."
34010713
reach
"However, IL-1 alpha and IL-1 beta were better inducers of IL-1ra than was TNF-alpha."
8179914
reach
"IL-1alpha and IL-1beta are also produced, which activate an IL-1R1 and MyD88-positive feedback loop in macrophages and IL-1R on other resident cells in the cornea."
20826748
reach
"IL-1R is activated by its ligands IL-1alpha and IL-1beta [XREF_BIBR; XREF_BIBR]."
22137885
reach
"IL-1alpha or TNF-alpha alone, and particularly the combination of both cytokines, stimulated the production of IL-1Ra in contrast to HDF."
15036245
bel
"In addition, IL-1α, which also activates IL-1R, could contribute to the inflammatory response in vivo."
23702978
sparser
"We also show that P. aeruginosa activates NF-κB in macrophages through both the TIR-containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF-dependent pathways, and that IL-1α and IL-1β activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
sparser
"Following EGFR activation IL-1α is released and activates IL-1R on keratinocytes creating a second autocrine loop leading to the activation of NF-κB signaling that modifies expression of specific keratinocyte genes involved in tumor formation including increasing expression and release of CXC ligands such as CXCL1 ( xref )."
27330189
sparser
"IL-1 α is released from the damaged cardiomyocytes and activates IL-1R1 on cardiac fibroblasts, inducing early myocardial remodeling in AMI [ xref ]."
33488934