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Statements


OTUD3 deubiquitinates CGAS. 2 / 2
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"However, OTUD3 WT could not deubiquitinate cGAS compared with OTUD3 CA ( Figure S4 B), which indicates OTUD3 WT cannot remove specific K27-linked polyUb of cGAS catalyzed by RNF185."

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"This result indicates that deubiquitination of cGAS by OTUD3 enhances the DNA-binding ability of cGAS."