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BAP1 increases the amount of CD274. 4 / 4
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"We found an obvious increase in the total extent of H2AK119Ub in Bap1-KO MC38 cells compared to WT cells (Fig. 1f) and re-expression of WT human BAP1 but not a catalytical inactive BAP1 Cys91-Ala (C91A) variant [18] in Bap1-KO cells rescued both cell-surface PD-L1 accumulation levels and Cd274 mRNA expression (Fig. 1j, k), indicating that Bap1-mediated regulation of PD-L1 expression is dependent on its enzymatic activity."
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"BAP1 overexpression significantly increased the expression of SP1, YAP, PD-L1, CAS6, AXL, and downstream signaling proteins (PI3K, STAT3, ERK½, MMP-2, and MMP-9), while BAP1 knockdown reduced their levels."
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"The results of our study showed no significant impact of BAP1 loss and expression of PD-L1 ≥ 1% on patient survival ( p = 0.541) or on time to disease progression ( p = 0.589)."
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"Moreover, BAP1 inactivation significantly increased the mRNA expression of the immune checkpoint receptors CD274 (PD-L1), PDCD1 (PD-1), and LAG3 (LAG3) in primary TCGA tumors, which are critical mediators of T-cell exhaustion40 (Fig. 4D, E)."
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