IndraLab

Statements

TGFB1 binds CD4. 5 / 5
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"Inasmuch as the surface bound TGF-beta was detected by Abs whose target epitopes reside in both active TGF-beta and LAP, it is likely that surface TGF-beta1-positive CD4 + CD25 + T cells bind functionally inactive TGF-beta1 still associated with LAP."
11535631
sparser
"It is known that interaction of membrane-bound TGF-β1 with CD4 + T cells induces anergy ( xref , xref )."
21551366
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"However, another study showed that the CD13 + CD4 + CD25 hi Treg subpopulation exhibits stronger suppressive function among CD4 + CD25 hi Treg cells by expressing a higher level of Foxp3, CTLA-4, membrane bound TGF-beta1, and B7H1."
31848300
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"To determine if TGF-beta1 -/- CD4 + T-cells could bind free latent TGF-beta1, unfractionated CD4 + T-cells were activated for 48h, incubated with human latent TGF-beta1, washed and then stained for human LAP (XREF_FIG)."
23645881
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"These findings, plus the observation that suppression requires cell-cell contact, lead us to the conclusion that CD4 + CD25 + T cell mediated immunosuppression is mediated by cell surface bound TGF-beta1."
11535631