IndraLab

Statements

CYLD inhibits NFKB1. 3 / 3
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"Loss of CYLD up-regulates NFKB signaling and enhance metastasis in breast cancer [37]."
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"CYLD is downregulated in several cancers and inhibits the NFkB pathway [XREF_BIBR, XREF_BIBR]."
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"Even though the extensively studied deubiquitinases CYLD and A20 are also known to negatively regulate NFkB activation, as does MCPIP, the target substrate and physiological functions of virtually all deubiquitinases remain obscure."
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