IndraLab

Statements

CYLD inhibits NFKB1. 6 / 6
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"CYLD is downregulated in several cancers and inhibits the NFkB pathway [XREF_BIBR, XREF_BIBR]."
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"CYLD overexpression has been reported to inhibit osteoclast formation by negatively regulating the NF-KB pathway, thereby reducing bone loss [16, 17]."
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"Even though the extensively studied deubiquitinases CYLD and A20 are also known to negatively regulate NFkB activation, as does MCPIP, the target substrate and physiological functions of virtually all deubiquitinases remain obscure."
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"Loss of CYLD up-regulates NFKB signaling and enhance metastasis in breast cancer [37]."
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"In vitro studies have suggested that CYLD negatively regulates the p65/p50 NF-κB pathway by removing K63-linked polyubiquitin chains from TRAF2/6 ( Brummelkamp et al., 2003; Kovalenko et al., 2003; Ma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, we used Poly dA:dT and Poly I:C as stimuli and confirmed that knockdown of CYLD could enhance activation of the NF-KB pathway."
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