IndraLab

Statements

COPS6 leads to the deubiquitination of FBXW7. 2 / 2
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"Previous study has shown that CSN6 enhanced the autoubiquitination and degradation of FBXW7 (a subunit of SCF ubiquitin ligase) 35, which could target mTOR and regulate its ubiquitination and degradation processes 36."
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"CSN6 promotes c-Myc-driven tumorigenesis by enhancing the neddylation of Cullin-1 and facilitating autoubiquitination/degradation of Fbxw7, which stabilizes c-Myc and upregulates Myc target genes [72][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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