IndraLab

Statements

COCH inhibits KCNK2. 5 / 5
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"Physiological concentrations of multimeric but not monomeric cochlin reduce TREK-1 current."
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"Physiological concentrations of multimeric but not monomeric cochlin reduce TREK-1 current."
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"In the diseased model, as supported by our data, multimerized cochlin decreases TREK-1 current, which may in turn decrease outflow, as a result of the cellular structure changes induced by the interaction of both proteins."
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"Multimeric cochlin induced a statistically significant decrease in TREK-1 current of 36.8 +/-11.2%; n = 5; p < 0.05 vs. baseline; Fig."
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"TREK-1 basal channel activity was strongly reduced by multimerized cochlin at physiological concentrations (10nM)."
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