IndraLab

Statements


OTUB1 activates NR4A1. 4 / 4
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"As expected, the overexpression of Trim13 reduced the stability of Nur77, but co-transfection of OTUB1 with Trim13 restored the stability of Nur77 ( Fig. 6 A )."

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"The knockout of OTUB1 lead an attenuation of Nur77 protein despite the absence of changes in the Nur77 mRNA level ( Figs."

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"To further investigate the mechanism of OTUB1-mediated Nur77 stabilization, we examined the interaction between OTUB1 and Nur77."

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"That is, OTUB1 or OTUB2 suppressed Nur77 degradation which was increased by CHX treatment ( Fig. 4 C)."