IndraLab

Statements

USP22 binds AKT. 5 / 5
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"The interaction of AKT with USP22 was detected in transiently transfected HEK293T cells as well as in human MDA-MB-231 breast cancer cells ( xref )."
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"Stimulation of MDA-MB-231 breast cancer cells with EPI markedly enhanced both AKT and USP22 interaction ( xref ) as well as their phosphorylation (fig."
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"Conversely, treatment with the AKT-specific inhibitor facilitated USP22 protein degradation ( xref ), increased the USP22 ubiquitination ( xref ), and inhibited the AKT and USP22 interaction in breast cancer cells ( xref )."
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"Conversely, treatment with the AKT-specific inhibitor facilitated USP22 protein degradation (Fig. 5, K and L), increased the USP22 ubiquitination (Fig. 5M), and inhibited the AKT and USP22 interaction in breast cancer cells (Fig. 5N)."
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"Of note, mass spectrometry (MS) analysis also detected 10 AKT phosphorylated peptides in the anti-USP22 immunoprecipitants ( xref ), confirming our initial discovery of AKT-USP22 interaction and suggesting that USP22 interacts with the phosphorylated AKT upon EPI stimulation in breast cancer cells."
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