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BAP1 activates S phase. 3 / 3
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"Similarly, downregulation of BAP1 markedly increased cells in the S phase and reduced cells in the G0/G1 phase, consistent with the results of a recent study that depletion of BAP1 resulted in a modest accumulation of host cell factor 1, which promoted the transition from G1 to S phase ."
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"BAP1 knockdown downregulated E2F1 target genes essential for S phase initiation and subsequent G1/S transition (shown in Fig. 2 )."
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"Lost expression of BAP1 seems to promote the survival of H28 cells, reducing effects of transfection on cell cycle block, while normal levels of BAP1 in wild type cells H2052 caused a S-phase retardat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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