IndraLab

Statements

USP18 decreases the amount of MIR7-1. 4 / 4
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"The ubiquitin specific peptidase Usp18, the RNA binding protein QKI-5/-6, HuR and MSI2 and the circular transcript ciRS-7 showed to down-regulate the level of miR-7."
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"Conversely, Usp18 inhibits transcription of miR-7 from all three loci in multiple cancer cell lines ( Duex et al., 2011 ), promoting tumorigenicity and expression of miR-7 target mRNAs such as the EGF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Through a mechanism not fully elucidated, that requires its catalytic activity, USP18 can negatively regulate miR-7 expression."
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"Usp18 decreases the expression of miR-7 host genes, as well as intergenic pri-miR-7-2 [XREF_BIBR]."
| PMC