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SISR inhibits KCNH2. 1 / 1

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"Voltage-clamp electrophysiological studies have shown that SISR, such as fluoxetine and norfluoxetine, one of its metabolites, selectively block hERG channels via two different mechanisms : (i) direct channel blockade, and (ii) disruption of channel protein trafficking."

22590457

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IndraLab

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SISR inhibits KCNH2. 1 / 1

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