IndraLab

Statements

OTULIN inhibits apoptotic process. 8 / 8
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"Indeed, our data also revealed that OTULIN deficiency increases the sensitivity of osteosarcoma cells to apoptosis and necroptosis induced by cisplatin."
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"Together, these data demonstrate that OTULIN is critical to prevent IEC apoptosis in conditions of acute TNF exposure."
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"Notably, D31E OTULIN-expressing cells displayed enhanced caspase-3 processing ( Figures 3 C and 3D) and were more sensitive to apoptosis than WT cells ( Figure 3 E), suggesting that OTULIN processing,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The OTULIN mediated suppression of hepatocyte apoptosis plays a crucial role in liver pathogeneses, such as hepatitis, fibrosis, and hepatocellular carcinoma [XREF_BIBR]."
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"OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis."
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"OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated apoptosis in hepatocytes [55]."
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"OTULIN positively affects LUBAC by inhibiting its auto-ubiquitination, and OTULIN deficiency leads to TNFα-induced apoptosis and necroptosis (94, 95)."
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"In addition, OTULIN prevents liver cancer by limiting apoptosis."
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