IndraLab

Statements

UCHL5 deubiquitinates SMAD2. 6 / 6
2 | 4
reach
"UCH5/UCH37 deubiquitinates both smad2 and smad3 to promote TGFβ-1 induced lung fibrosis [70]."
32650621
reach
"In the present study, we demonstrate that UCHL5 de-ubiquitinates and stabilizes Smad2 and Smad3, thereby promoting TGFbeta-1 signaling."
27604640
signor
"Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases"
16027725
signor
"Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the -py- motif in smad7 that interacts with smurf ubiquitin ligases"
16027725
reach
"Here, we demonstrate that UCHL5 de-ubiquitinates and stabilizes Smad2 and Smad3, thereby promoting TGFbeta-1 signaling and contributes to the pathogenesis of pulmonary fibrosis."
27604640
reach
"Also, OTUB1 regulates only phosphorylated Smad2 and Smad3 under TGFbeta-1 treatment XREF_BIBR, while UCHL5 de-ubiquitinates Smad2 and Smad3 regardless of TGFbeta-1 treatment."
27604640