IndraLab

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TAFAZZIN increases the amount of USP22. 2 / 2
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"Taz enhanced USP22 expression at both the mRNA and protein levels in various colon cancer cell lines, including HCT116, SW480, LS180, and MC38 cells (Figure 3A; Figure S3C,D, Supporting Information)."
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"This suggests that EZH2 regulates USP22 expression through its SET domain‐mediated histone methylation activity.The immunofluorescence results similarly indicated that Taz treatment upregulated the cellular expression of both USP22 and PD‐L1 (Figure 3H)."
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