IndraLab

Statements

USP38 binds JUNB. 6 / 6
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reach
"USP38 directly associates with JunB and removes TCR-induced JunB poly-ubiquitination."
30224386
reach
"We demonstrated that USP38 directly associated with JunB and removed its poly-ubiquitination to block JunB degradation in TCR signaling, thus initiating Th2 differentiation and driving allergic asthma."
30224386
reach
"USP38 associated with JunB directly as well as in a TCR signal–dependent manner."
30224386
reach
"We then checked into the endogenous system and found that USP38 bound to JunB, but not c-Jun, in a TCR stimulation–dependent manner (Fig. 9 B)."
30224386
reach
"USP38 did not associate with Itch, nor its activator Ndfip1, in either 293T overexpression system or TCR-induced endogenous system (Fig. 9, A and B), indicating that USP38 may directly associate with JunB for its deubiquitination."
30224386
reach
"All these data suggest that USP38 directly associates with JunB, and its enzyme activity removes JunB ubiquitination in TCR signaling."
30224386