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"For example, in male pups the expression of the gene Kcnq1 , a voltage-gated potassium channel, which has been associated with Jervell and Lange-Nielsen syndrome and hereditary long QT syndrome 1 [ xref , xref ], and the gene Tsix that expresses the non-coding antisense transcript required for imprinted X inactivation [ xref ], were down-regulated."