IndraLab

Statements

OTUB2 inhibits CD274. 3 / 3
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"Additionally, Ren et al. demonstrated that the pharmacological targeting of OTUB2 promotes PD-L1 degradation, increasing the sensitivity of tumor cells to T cells."
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"These results indicate that depletion of OTUB2 enhances antitumor immunity by regulating PD-L1 abundance and activating CTLs."
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"OTUB2 mediates ER-dependent degradation of PD-L1."
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