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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP26 inhibits SMAD7. 2 / 2

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"As observed with USP26 knockdown, ectopic expression of the DUB dead mutant recapitulated the augmentation of SMAD7 induction by TGF-beta whereas wild-type USP26 significantly diminished the induction of SMAD7 in the presence of TGF-beta (Fig XREF_FIG F)."

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"Therefore, we analyzed whether loss of USP26 increases the levels of SMAD7 Lys48 or Lys63 incorporated ubiquitin chains."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...