IndraLab

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USP18 deubiquitinates TAB1. 6 / 6
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"To further examine whether USP18 deubiquitinates the TAK1 and TAB1 complex, we purified Flag tagged USP18 from 293T cells transiently transfected with Flag-USP18 plasmid by immunoprecipitation with anti-Flag agarose and elution with Flag peptide."

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"Importantly, USP18 is associated with and deubiquitinates the TAK1 and TAB1 complex, thereby restricting expression of IL-2."

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"In contrast, they suggest that USP18 inhibits ubiquitination of the TAK1 and TAB1 complex in a protease dependent manner XREF_BIBR, XREF_BIBR."

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"In contrast, they suggest that USP18 inhibits ubiquitination of the TAK1/TAB1 complex in a protease dependent manner30,31."

"USP18 is associated with and deubiquitinates the TAK1-TAB1 complex"

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"Previous studies showed that USP18 potently abolishes the polyubiquitination of TAK1 and TAB1 complex XREF_BIBR."