IndraLab

Statements

KCNMA1 activates immune response. 6 / 6
| 6
reach
"A multivalent non-M protein vaccine, VAX-A1 composed of SpyAD-GAC , SCPA, and SLO antigens stimulated systemic immunity with the goal of broad protection of GAS strains without autoreactivity following the intravenous administration route in mice [110]."
38543906
reach
"Protective immunity is mediated by neutralization of active SLO."
23300245
reach
"A non toxic SLO derivate elicits protective immunity against lethal GAS challenge in a murine infection model."
26635795
reach
"SLO toxin can prevent neutrophil degranulation and elicit further protective immunity if administered in subcytotoxic concentrations (56)."
37588093
reach
"SLO maintains immune homeostasis and promotes a rapid and effective immune response (83)."
35990622
reach
"Taken together, these results indicate that less toxic SLO variants that produce strands and altered pores could promote a more robust immune response through enhanced cytokine secretion."
23744055