IndraLab

Statements

Hydroxychloroquine inhibits IL17A. 13 / 14
| 2 11
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"Evidence from an in vitro study suggests that hydroxychloroquine might inhibit the production of IL-6 and IL-17A [66]."
31933536
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"9 Previous reports revealed that HCQ inhibits the differentiation of Th-17 cells and decreased the release of IL-17 from the experience of treating systemic lupus erythematosus."
| PMC
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"Our in vitro results demonstrated that hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production and contributes to a better understanding of the mechanism of action of this medication."
23778483
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"Hydroxychloroquine, a drug often used in the treatment of SLE with ability to reduce sensitivity of the skin to UV exposure, can inhibit Th17 cell expansion and IL-17 production [XREF_BIBR]."
27597882
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"Hydroxychloroquine also has immunomodulatory effects, and has been reported to decrease IL-1, IL-2, IL-6, IL-17, IL-22, IFN-alpha, and tumor necrosis factor [XREF_BIBR, XREF_BIBR]."
| PMC
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"A previous study also confirmed that HCQ inhibit differentiation of Th17 cell and production of IL-17 (Yang et al. 2018)."
35705919
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"Furthermore, considering that the levels of systemic inflammation biomarkers significantly decreased among good responders in our study, it is notable that methotrexate alone or in combination with sulfasalazine reduces circulating levels of IL-6 [XREF_BIBR], and hydroxychloroquine inhibits IL-6, IL-17 and IL-22 production from PBMC [XREF_BIBR]."
26353115
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"HCQ significantly reduces the production of cytokines (IL-6, IL-8, IL-17 and IL-22 and TNF-α, Il-1, soluble CD8 and soluble IL2 receptors) and induces the normalization of complement activity [ 21 , 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30316994
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"Contrarily , CQ and HCQ inhibited IL-1 , IL-2 , IL-6 , IL-17 , and IL-22 as well as PGs ( Table 1 ) [ 61 , 98 , 99 ] ."
33062720
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"In experiments with rodents and PBMC isolated from SLE and HIV patients, HCQ attenuated Th17 differentiation, proliferation, and production of IL-17 while promoting the immunosuppressive effect of Tregs (Piconi et al., 2011; An et al., 2017; Yang et al., 2018; Kowatsch et al., 2023)."
38375029
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"The exact mechanism via which HCQ decreased IL-6 and IL-17 as well as IL-22 concentrations is still a matter of debate ."
33062720
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"Furthermore, Yang et al. found that HCQ reduced the differentiation of Th17 cells and the production of IL-17A in vitro using PBMCs from SLE patients (13)."
35401507
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"In vitro, HCQ inhibited Th17 cell proliferation and differentiation, as well as IL-17 production."
29545450