IndraLab

Statements

Lidocaine inhibits KCNH2. 11 / 11
1 | 4 6
sparser
"Lidocaine inhibited hERG current in a concentration-dependent manner at 0.3-1 000 μmol·L(-1), the IC(50) value was 88.63 ±7.99 μmol·L(-1)."
29908112
sparser
"The IC 50 for inhibition of Y652A I hERG by lidocaine was 554.33 ± 34.03 μM ( h  = 0.95 ± 0.06), ~ 3.8-fold the corresponding value for WT hERG."
24877995
sparser
"The IC 50 for outward I hERG tail inhibition by lidocaine in 4 mM [K + ] e was 141.77 ± 9.81 μM ( h  = 0.98 ± 0.07), with an IC 50 for inward I hERG in high [K + ] e increased to 735.32 ± 54.03 μM ( h  = 0.82 ± 0.05)."
24877995
reach
"Thus, flecainide inhibits hERG currents by 81% at 10mum and lidocaine inhibits hERG by 25% at 100 muM."
18493243
sparser
"The effect of Y652A on I hERG inhibition by ranolazine and lidocaine is shown in xref C and D (with the standard voltage protocol used for WT I hERG )."
24877995
sparser
"However, lidocaine inhibited hERG current in a frequency-dependent manner."
29908112
reach
"However, lidocaine inhibited hERG current in a frequency dependent manner."
29908112
sparser
"The effects of all of the studied hERG mutants on the potency of inhibition of I hERG by both ranolazine and lidocaine are summarized in supplementary Tables S1 and S2."
24877995
reach
"Lidocaine inhibited hERG current in a concentration dependent manner at 0.3-1 000 mumol.L (-1), the IC (50) value was 88.63 +/-7.99 mumol.L (-1)."
29908112
ctd
No evidence text available
24052561
reach
"Finally, 100muM of lidocaine inhibited ~ 25% of WT hERG current, which reflected its poor affinity towards hERG."
33004839