IndraLab

Statements


Phosphorylated EGFR binds GRB2 and SH2 domains. 1 / 1
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reach
"Cbl proteins are recruited to the activated EGFR either by the direct binding of their TKB domain to the phospho-tyrosine residue at position 1045 in the EGFR, or by an indirect mechanism mediated by Grb2, as the SH3 domains of Grb2 bind the proline rich region of Cbl proteins and the SH2 domains of Grb2 binds the phosphorylated EGFR."