IndraLab

Statements

TNFAIP3 activates Ubiquitin. 4 / 4
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"TNFAIP3 protein as a zinc finger protein and ubiquitin shearing enzyme can suppress activated NF-kappaB signal pathway and induce apoptosis of TNF by activating ubiquitin ligase and ubiquitinase."
32368089
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"In addition to TNFAIP3 modulating ubiquitin others have found that TNFAIP3 can also inhibit IKK complex activity through a mechanism that is independent of ubiquitin."
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"Therefore, it is plausible that TNFAIP3 mediated ubiquitin editing contributes to the modification of tight junction proteins."
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"Although TNF gene expression was not found to be altered in ACC, the tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a ubiquitin-modifying enzyme that negatively regulates TNF response, was found to be overexpressed in ACC when compared to the normal adrenal gland."
30978697